Association between maternal periodontal status, inflammation, and early weight development in the offspring. The PROBE intervention study — ASN Events
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  3. Association between maternal periodontal status, inflammation, and early weight development in the offspring. The PROBE intervention study

Association between maternal periodontal status, inflammation, and early weight development in the offspring. The PROBE intervention study (#332)

Sarah Naeem SNB Butt 1 2 , Karoline KW Winckler 1 , Anette AA Andersen 3 4 , Christian CD Damgaard 5 , Berit Lilienthal BH Heitmann 1 6 7
  1. Frederiksberg Hospital, Region Hovedstaden, København, Denmark
  2. Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Danmark
  3. Steno Diabetes Center Aarhus, , Aarhus University Hospital, Aarhus, Danmark
  4. Department of Public Health, Aarhus University, Aarhus, Danmark
  5. Department of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Danmark
  6. ; The Boden Group, Charles Perkins Centre, University of Sydney, Sydney, Australia
  7. Section for General Medicine, University of Copenhagen, Copenhagen, Danmark

Background: Systemic effects of maternal periodontal inflammation during pregnancy can potentially affect the development and metabolism of the offspring. Studies show that maternal systemic low-grade inflammation can affect fetal growth and lead to lower birth weight and reduced growth in early infancy. Treating periodontal inflammation during pregnancy may therefore promote healthier weight development in the offspring. 

Aim: The aim is to determine whether periodontal treatment during pregnancy can reduce systemic low-grade inflammation and contribute to a healthier early weight development in the offspring. 

Methods: The study includes 400 pregnant women with periodontitis recruited to the PROBE study (Periodontal treatment during pregnancy), a controlled intervention study in Region Zealand, Denmark. Included pregnant women received periodontal treatment either during pregnancy (intervention group, n=200) or postpartum (control group, n=200). The women provided three venous blood samples and completed three questionnaires about their own and their child’s health, including information about medication use. The blood samples were analyzed for inflammatory, hormonal, and glucose markers. Data about the offsprings growth patterns was collected through questionnaires when the child is two and six months and will be retrieved from the health nurses’ journals at 10 months of age.  

Preliminary results and conclusion: The PROBE project and design, as well as preliminary results will be presented on the conference.