<em>Early post-transplant hyperglycaemia and post-transplant diabetes mellitus in lung transplant recipients </em><em> </em>   — ASN Events
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Early post-transplant hyperglycaemia and post-transplant diabetes mellitus in lung transplant recipients     (#327)

Nicola Awad 1 , Christopher A Muir 2 , Lisa M Raven 2
  1. School of Clinical Medicine, Faculty of Medicine and Health, Sydney, New South Wales, Australia
  2. Department of Endocrinology, St Vincent's Hospital, Sydney, New South Wales, Australia

Aims: Post-transplant diabetes mellitus (PTDM) is a well-recognised complication of solid organ transplantation, but early-post transplant hyperglycaemia (EPTH) is yet to be formally defined or characterised in lung transplant recipients. We aimed to determine the prevalence of EPTH and cumulative 5-year prevalence of PTDM in a modern cohort of lung transplant recipients who were free from diabetes at time of transplant.  

Methods: Single centre retrospective cohort study of patients who received a lung transplant between 2018-2020.   

Results: Of 115 lung transplant recipients, 13 (11%) had pre-existing diabetes mellitus. In those free from diabetes at time of transplant, EPTH developed in 72 (71%). At 3 months post-transplant PTDM developed in 45 of 102 (44%) recipients without pre-existing diabetes, in which 24 (93%) had experienced EPTH. At 5 years post-transplant, the prevalence of PTDM was 55% (n=56). In the subgroup of lung transplant recipients with cystic fibrosis (n=18), 6 had pre-existing diabetes, and the remaining 12 developed EPTH and/or PTDM. 

Conclusion: EPTH and PTDM are highly prevalent in lung transplant recipients, with >70% experience hyperglycaemia in the immediate post-transplant phase. EPTH develops within days of transplant and is strongly associated with progression to PTDM.