CREBRF: Uncoupling obesity from type 2 diabetes

CREBRF: Uncoupling obesity from type 2 diabetes

CREBRF: Uncoupling obesity from type 2 diabetes (#227)

Rinki Murphy ¹

University of Auckland, Auckland, New Zealand

The discovery of the novel CREBRF variant unique to people of Māori or Pacific ancestry, challenges the traditional paradigm linking obesity to type 2 diabetes due to its paradoxical association with higher BMI, taller height, but lower risk of type 2 diabetes and gestational diabetes. This presentation will review evidence from our New Zealand genetic, physiological and clinical studies showing that CREBRF influences insulin secretion, body composition and gestational diabetes, providing insights into mechanisms of metabolic resilience despite higher body mass.

Authors contributing to this presentation.

Murphy, R

Rinki Murphy is an endocrinologist with a special interest in monogenic forms of diabetes and severe insulin resistance. Since completing her PhD in genetics and epigenetics of diabetes at the University of Plymouth in 2007, she returned to work in Auckland at both Auckland and Counties Manukau District Health Boards, and is a senior lecturer in medicine at the University of Auckland. She established the national monogenic diabetes guidelines and research database (www.nzssd.org.nz), and conducts research in the two broad areas of genetics and physiology of diabetes and obesity.

CREBRF: Uncoupling obesity from type 2 diabetes (#227)

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Murphy, R

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